Comparative analysis of the expression of the soluble IL-7 receptor in patients with arthropathy

Arthropathy is one of the most prevalent diseases, which are based on destruction and remodeling cartilage bone tissue. The inflammation that precedes can be caused by mechanical stress joints, or autoimmune reactions. Recently, IL-7 considered as key cytokines promote production matrix metalloproteinases, catabolic enzymes, T cell-mediated activation monocytes, maturation osteoclasts. soluble form receptor help prolong lifespan thereby it ensures bioavailability cytokine mediates effect cells. aim this study was to determine (sIL-7R) in blood plasma patients with rheumatoid arthritis (RA), osteoarthritis (OA), psoriatic (PsA) psoriasis vulgaris (PS), well healthy individuals. RA included had moderate high disease activity according DAS28 index. Patients PsA predominantly low (DAS28) were characterized mild severity (PASI). In accordance PASI index, PS severe study. All OA a metabolic phenotype accompanied an elevated body mass sIL-7R determined enzyme-linked immunosorbent assay. It found arthropathy, level increased relative individuals, exception group PsA. Also, concentration observed PS. Analyzing clinical characteristics patients, we levels DAS28. addition, positive correlations between (PASI), also donor's values. On contrary, PS, noted regardless disease. OA, no relationship parameters. Thus, arthropathy may indicate involvement its system pathogenesis joint diseases. become promising target both treatment diseases other including psoriasis.